The Phenolic Components of Gastrodia elata improve Prognosis in Rats after Cerebral Ischemia/Reperfusion by Enhancing the Endogenous Antioxidant Mechanisms

Figure 4

Histological features of the penumbra in cerebral I/R rats (H&E staining): (a) sham group; (b) vehicle group; (c) 30 mg/kg Nimodipine group; (d) 40 mg/kg PCGE group; (e) 4 mg/kg PCGE group. Bar = 20 μm. In the sham group, the cortex showed many normal neurons (arrowheads) and astrocytic nuclei (arrows). In the vehicle group, ischemic penumbra showed shrunken, dense, and angular neurons (arrowheads) and swollen astrocytic nuclei (arrows). Nimodipine or PCGE treatment reduced the pathological lesions in the penumbra of cerebral I/R rats.