Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans

<div>Lipid peroxidation (LPO) and advanced oxidation protein product (AOPP) levels in plasma of subjects of three studied groups ((a) and (b)). LPO and AOPP levels in plasma were also classified according to gender ((c) and (d)). 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transform="matrix(.013,0,0,-0.013,49.366,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg> versus the control group. Correlation analysis between miR-21 relative expression and AOPP levels (e), calculated using analysis of the Spearman correlation coefficient. C: control group; R: robust group; F: fragile group.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans 