Biotoxicological Analyses of Trimeroside from Baccharis trimera Using a Battery of In Vitro Test Systems

Table 3

Genotoxicity parameter (mean ± SD) for HepG2 exposed to different concentrations of trimeroside.

Groups	Comet assay (400 cells/dose)
	Damage index (0–400)	Damage frequency (%)
Negative control	11.7 ± 6.9	9.7 ± 5.3
Positive control	119.5 ± 24.7	75.0 ± 1.4
0.25 mg·mL^−1	16.3 ± 2.2	14.7 ± 2.7
0.50 mg·mL^−1	16.7 ± 5.9	15.5 ± 6.1
1.00 mg·mL^−1	21.2 ± 3.8	17.7 ± 4.3
1.50 mg·mL^−1	16.2 ± 4.2	14.0 ± 2.7
2.00 mg·mL^−1	15.5 ± 4.5	12.7 ± 3.6

DMSO 0.5%; MMS 8 × 10⁻⁵ M. Significant in comparison to the negative control at (ANOVA, Tukey test).