Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Table 1

Effects of atorvastatin after cotreatment with alkylating agents on Salmonella enterica typhimurium strains TA104 and TA102.

Atorvastatin; (μM)		Coincubation	TA104			TA102
			His^+	MI	% reduction	His^+	MI	% reduction
—	−S9	DMSO 1%		1.00	—		1.00	—
0	−S9	MMS; (100 μM)		2.24	0.00		2.31	0.00
20	−S9			2.00	19.36		2.10	16.03
100	−S9			1.94	24.19		2.06	19.08
200	−S9			1.84	32.26		1.93	29.01
1000	−S9			1.55	55.65		1.77	41.22
—	+S9	DMSO 1%		1.00	—		1.00	—
0	+S9	CPA; (150 μM)		2.40	0.00		2.1	0.00
20	+S9			2.13	19.29		2.02	7.27
100	+S9			2.05	25.00		2.00	9.09
200	+S9			1.99	29.29		1.94	14.55
1000	+S9			1.82	41.43		1.77	30.00

MMS: methyl methanesulfonate; CPA: cyclophosphamide; His⁺: revertant colonies; MI: mutagenicity index. versus only MMS or only CPA (one-way ANOVA followed by a Dunnett’s post hoc test).