Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries

Table 3

Effects of atorvastatin after pretreatment and posttreatment with alkylating agents on Salmonella enterica typhimurium strain TA100.

Atorvastatin; (μM)			TA100
			Pretreatment			Posttreatment
			His^+	MI	% reduction	His^+	MI	% reduction
—	−S9	DMSO 1%		1.00			1.00	—
0	−S9	MMS; (100 μM)		2.26	0		2.09	0
20	−S9			1.68	45.97		2.03	5.69
100	−S9			1.14	88.57		1.96	11.86
200	−S9			1.11	91.43		1.87	20.10
1000	−S9			1.02	98.7		1.84	23.00
—	+S9	DMSO 1%		1.00	—		1.00	—
0	+S9	CPA; (150 μM)		2.44	0		2.66	0.00
20	+S9			1.30	79.4		2.46	12.04
100	+S9			1.27	81.6		2.37	17.44
200	+S9			1.11	92.59		2.34	18.49
1000	+S9			1.03	97.92		2.30	21.48

MMS: methyl methanesulfonate; CPA: cyclophosphamide; His⁺: revertant colonies; MI: mutagenicity index. versus only MMS or only CPA (one-way ANOVA followed by a Dunnett’s post hoc test).