Anti-Inflammatory Effect of a Polyphenol-Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages and Acetaminophen-Induced Liver Injury in Mice

Figure 9

Effect of PEF on proinflammatory cytokines production in APAP-intoxicated mice. Mice were intragastrically administered with either PBS or PEF (100, 200, and 400 mg/kg body weight) once daily for 7 consecutive days prior to a single administration of APAP (500 mg/kg body weight). Mice were killed at 6 h after APAP challenge. Serum concentrations of (a) TNF-α, (b) IL-1β, and (c) IL-6 were determined by the commercial ELISA kits. Results are shown as the mean ± SD (). The different letters represent the statistical differences at among the groups by Tukey-Kramer’s test.

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(b)

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