Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells

Figure 2

Antioxidative effect of cafestol on cyclic-strain-induced ROS production and inflammatory molecule secretion in HUVECs. Cells were pretreated with cafestol (10 μM) for 12 h or NAC (10 mM) for 2 h and then exposed to cyclic strain for 24 h. (a) ROS production was assayed using DCF. (b) Protein expression levels were examined using ELISA. The bar graph shows the fold increase in protein secretion compared with control cells. Results are shown as the (). versus untreated controls; versus cells exposed to cyclic strain.

(a)

(b)