Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity

<div>TSG inhibited 6-OHDA-induced DA neuronal loss in the SN <i>in vivo</i>. Brain sections were immunostained with an anti-TH antibody (a). The “ellipse” presented the area of SN. Scale bar = 200 <i>μ</i>m. The number of TH-positive neurons in the SN was counted (b). Rat behavior changes were analyzed by rotarod test. The time that the rats remained on the rod was recorded (c). The DA (d) and DOPAC (e) levels in rat brain striatum were measured by HPLC coupled with electrochemical detection. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity 