Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis-Induced Acute Kidney Injury
Urinary mitochondrial DNA (UmtDNA) levels are increased and correlated with renal injury following cecal ligation and puncture (CLP). Rats underwent sham surgery and CLP, and rats were placed in metabolic cages after CLP for urine collection. UmtDNA levels were significantly increased following sepsis induced by CLP (a) and correlated with serum creatinine (b) and BUN (c). .