Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway

Figure 5

Resveratrol-enriched rice modulates AP-1 effector signaling in lipopolysaccharide-activated BV2 microglial cells. BV2 microglial cells were treated with samples, followed by LPS (100 ng/mL) activation. AP-1 signaling was evaluated after incubation of cells for 1 h. AP-1 expression was measured pretreatment in LPS-activated BV2 cells. (a, b) p-C-Fos/C-Fos protein expression and band intensity, and (c, d) p-C-Jun/c-Jun expression and band intensity after incubation with LPS and samples for 1 h in BV2 cells. All data are presented as the mean ± standard error of the mean of three independent experiments. , , and indicate significant differences compared with LPS treatment alone. and indicate significant differences compared with untreated control group. indicates significant differences to RR compared to NR. Ctl, untreated control and LPS, lipopolysaccharide.

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