Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway

Figure 7

Treatment with resveratrol-enriched rice modulates MAPK signaling lipopolysaccharide-activated BV2 cells. BV2 microglial cells were pretreated with normal rice (NR), resveratrol-enriched rice (RR), and resveratrol 30 min prior to LPS (100 ng/mL) treatment. MAPK modulation was observed after 24 h of sample treatment and LPS activation. (a, b) JNK/pJNK expression and band intensity, (c, d) ERK/pERK expression and band intensity, (e, f) p38/pP38 expression and band intensity in LPS-activated BV2 microglia. All data are presented as the mean ± standard error of the mean of three independent experiments. , and indicate significant differences compared with LPS treatment alone. , and indicate significant differences compared with the untreated control group. Ctl, untreated control and LPS, lipopolysaccharide.

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