Gefitinib Inhibits Bleomycin-Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice

<div>Gefitinib treatment decreased the severity of pulmonary fibrosis. Lung tissues from gefitinib- (Ge-) treated and PBS-treated pulmonary fibrosis mice were collected two weeks after bleomycin (BLM) administration. (a) Pathologic findings of lung tissues stained by H&amp;E and Masson’s trichrome (magnification 200x). (b) Lung hydroxyproline levels were significantly decreased by gefitinib treatment. Semiquantitative scoring of the severities and extents of inflammation (b) and fibrosis (c) were reduced in the BLM + Ge group compared with the BLM group. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Gefitinib Inhibits Bleomycin-Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice 