Gefitinib Inhibits Bleomycin-Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice

Figure 8

Gefitinib treatment decreased HMGB1 expression and phosphorylation expressions of EGFR and MAPKs in the lung tissues affected by pulmonary fibrosis. Lung tissues from gefitinib- (Ge-) treated and PBS-treated pulmonary fibrosis mice were collected two weeks after bleomycin (BLM) administration. (a) The expression of HMGB1, total, and phosphorylation of EGFR/ERK/P38/JNK in the lung tissues were detected by Western blot. (b) The relative band densities were calculated. Gefitinib treatment significantly inhibited the protein activation of HMGB1 and the phosphorylation of EGFR and MAPKs induced by BLM administration in mice. All data were expressed as the mean ± SD, . versus BLM group.

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