Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

Figure 7

The ultrastructure of mitochondria in PANC-1 cells after treatment with 2.6 nm and 18 nm AgNPs for 24 h. (a) untreated PANC-1 cells. (b, c/d, e) cells treated with 2.6 nm AgNPs at concentrations of 0.5, 2.5, and 5 μg/mL, respectively. (f, g, h, i/j, k) cells treated with 18 nm AgNPs at concentrations of 5, 10, 25, 50, and 100 μg/mL, respectively. N: nucleus; m: mitochondria; arrow: AgNPs. Magnifications: (a–h) ×6000; (i) ×5000; (k) ×4000. Scale bars: (a–c) and (e–i) 1 μm; (k) 2 μm; (d, j) 500 nm.