Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway

Figure 2

Western blot analysis for Nrf2, heme oxygenase-1, and cleaved caspase-3. (a) Western blots for the measured factors in comparison to β-actin, lane 1 (saline), lane 2 (DOX control), and lanes 3, 4, and 5 (DOX in combination with BAs (125, 250, or 500 mg/kg). Column charts for fold changes in Nrf2 (b), heme oxygenase-1 (c), and cleaved caspase-3 (d). DOX: doxorubicin; BAs: boswellic acids; HO-1: heme oxygenase-1. Data are the mean ± SD, and analysis was done by one-way ANOVA followed by Tukey’s post hoc test. value < 0.05 compared to the saline group, value < 0.05 compared to the DOX group, value < 0.05 compared to the doxorubicin + BAs (125 mg/kg) group, and value < 0.05 compared to the doxorubicin + BAs (250 mg/kg) group.

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