Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection

Figure 3

Cardiac hypertrophy in Nrf2 KO and eNOS KO mice. (a) LV mass normalized to body weight illustrates cardiac hypertrophy in both Nrf2 KO and eNOS KO mice as compared to WT mice. (b) Diameter of left ventricular posterior wall measured at the end of systole highlights the increase in myocardial hypertrophy in both KO mice. (c) Representative B-mode pictures of the heart from different mouse strains visualize the extent of cardiac hypertrophy. Red bars show the diameter of the left ventricular posterior wall. WT mice: , Nrf2 KO mice: , eNOS KO mice: ; Browne-Forsythe test , means ± quartiles, one-way ANOVA , , , .

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