Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Table 1

MicroRNAs differentially expressed in ZO-Rap versus ZL-C and their similarity to microRNAs that were differentially expressed in ZL-Rap versus ZL-C.

MicroRNAs	ZO-Rap/ZL-C	ZL-Rap/ZL-C	Link to diabetes, fibrosis, and/or CVD
			Diabetes	Fibrosis	CVD
miR-200c/b	4.71/4.099	2.98/4.99	Increased [73, 74]	Suppressed [75]	Increased in familial hypercholesterolaemia [76]
miR-7a-1-3p	4.599	6.844	—	—	—
miR-138-1-3p	4.580	4.238	—		Suppresses cardiac hypertrophy [67, 77]
miR-21	4.533	5.305	Increased [59]	Increased [60]	Reduced in hypertension; cardioprotective [61–63]
miR-26b	4.428	5.147	—	—	Increased in hypertensive patients [78]
miR-434	4.345	9.322	Induces insulin resistance [79]		Increases atrial fibrillation, cardiac damage, heart disease [79–82]
miR-155	4.125	4.55	Increased in T1DM & T2DM [31, 32]	Increased [35]	Increased in cardiac hypertrophy and CHD [33, 34]
miR-30e-3p	4.06	4.80	Suppressed by insulin [45]	—	Suppression associates with cardiac injury [46]
miR-328b-3p	3.734	4.807	—	—	—
miR-505-3p	3.652	4.938	—	—	Increased in familial hypercholesterolaemia [83]
miR-382	3.407	4.56	Increased [84]	Increased [85]	—
miR-499	3.338	3.86	Induces insulin resistance [79]		Increases atrial fibrillation, cardiac damage, heart disease [79–82]
miR-872-5p	3.255	5.519	—	—	Associated with cardiac oxidative stress and atherosclerosis [86, 87]
miR-217	2.996	2.3409	Increased [88]	Increased [89]	Increased in cardiovascular aging [90]
miR-92b-3p	2.942	3.128	—	—	Suppressed in response to hypoxia [47]
miR-362-3p	2.907	6.316	Suppressed in DM patients [91]	Increased in cardiac fibroblasts [92]	Increased in acute myocardial infarction [93]

Please see Supplemental Table 4 for the exact gene expression levels and values.