Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Table 2

Similarities between differentially expressed microRNAs that modulate diabetes, cardiac fibrosis, and other cardiovascular diseases in ZO-C versus ZL-C and ZL-Rap versus ZL-C.

MicroRNA	ZO-C/ZL-C	ZL Rap/ZL-C	Nature of association with human or animal model pathology
			Diabetes	Fibrosis	CVD
miR-155	5.21	4.55	Increased in T1DM & T2DM [31, 32]	Increased [35]	Increased in cardiac hypertrophy and CHD [33, 34]
miR-200b/c	5.17/4.00	4.99/2.98	Increased [73, 74]	Suppressed [75]	Increased in familial hypercholesterolaemia [76]
miR-21	4.59	5.28	Increased [59]	Increased [60]	Reduced in hypertension; cardioprotective [61–63]
miR-26b-5p	4.41	5.13	—	—	Increased in hypertensive patients [78]
miR-872-5p	4.32	5.52	—	—	Associated with cardiac oxidative stress and atherosclerosis [86, 87]
miR-411-5p	3.89	7.16	—	Suppresses fibrosis [94]	Increased in abdominal aortic aneurism [95]
miR-382	3.84	4.56	Increased [84]	Increased [85]	—
miR-301a	3.81	4.86	Increased [96]		Increased in the diabetic heart [96]
miR-329	3.81	5.50	—	—	Increased in ischemia [97]
miR-350	3.68	3.61	—	—	Induces pathological cardiac hypertrophy [98]
miR-505-3p	3.66	4.92	—	—	Increased in familial hypercholesterolaemia [83]
miR-140	3.58	4.00	Reduced in platelets [99]	Suppresses fibrosis [100]	Suppresses pulmonary arterial hypertension [101]
miR-322	3.56	3.84	Suppressed by high glucose [102]	Suppresses fibrosis [103]	Improved cardiac function [103]
miR-362-3p	3.48	6.28	Increased [104]	—	Associated with atherosclerosis [105]
miR-374	3.34	5.94	—	—	Increased in cardiac hypertrophy and aneurism [106, 107]
miR-223-3p	3.27	3.56	Suppressed in DM patients [91]	Increased in cardiac fibroblasts [92]	Increased in acute myocardial infarction [93]
miR-204	3.20	7.01	Suppresses insulin [108]	—	Increases endoplasmic reticulum stress [109]
miR-98	3.20	3.41	Increased [110]	Reduces collagen [111]	Reduced in myocarditis [112]; increased in postheart transplant [113]
miR-34b	3.10	3.29	—	—	Reduced in diabetic ischemic heart failure [114]
miR-217	2.99	2.98	Increased [88]	Increased [89]	Increased in cardiovascular aging [90]
miR-541	2.97	3.18	Involved in pancreas development [115]	—	Suppresses cardiac hypertrophy [116]
miR-379	2.85	2.91	—	—	Apoptosis of VSMC [117]

Please see Supplemental Tables 1 and 2 for the exact gene expression levels and values.