Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Table 4

MicroRNAs differentially expressed in ZO-Rap versus ZO-C and their similarity to microRNAs that were differentially expressed in ZL-Rap versus ZL-C.

MicroRNA	ZO-Rap/ZO-C	ZL-Rap/ZL-C	Nature of Association with human or animal model pathology
			Diabetes	Cardiac fibrosis	CVD
miR-743a-5p	2.25	1.09;  = N.S.	—	—	Mediates mitochondrial oxidative stress [43]
miR-1843-3p	−2.25	2	—	—	—
miR-511-3p	−2.25	−1.7	—	—	Suppressed in moX-LDL-induced VSMC transformation in atherosclerosis [44]
miR-409b	−2.25	1.45;  = N.S.	—	—	—

N.S.: not significant. Please see Supplemental Table 3 for the exact gene expression levels and values.