Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Table 5

Differentially expressed miRNAs in ZL-C versus ZO-C and ZL-C versus ZL-Rap pairwise comparisons that target differentially expressed cytokines in the corresponding pairwise comparisons and as determined by binding sites on the 3 untranslated region of their mRNAs by in silico analysis in the corresponding sets.

miRNA	Targeted cytokines increased in			miRNA	Targeted cytokines
	ZO-C	ZL-Rap	Both		ZO-C	ZL-Rap
miR-21	CTACK, PDGFAA, CINC2	Notch2		miR-350		Notch2
miR-411	IL-2, IL-1α, TNF-α (2 sites)		IL-2, IL-10	miR-505	CINC2	Gas1
miR-7a	PDGFAA	IL-2, decorin, IL-22	IL-10	miR-217		Notch 2, IL-1α
miR-384-5p		IL-2, IL-10, Notch2		miR-541		Notch 2, CINC2
miR-30e		IL-22, Notch2	IL-10, IFNγ	miR-328b-3p		Notch 2, Gas1
miR-322			IFNγ	miR-29b		Notch 2
miR-382		Notch2	IFNγ, Prolactin	miR-455		Notch2
miR-742			IFNγ	miR-34b		Gas1
miR-539		IFNγ		miR-19a		Gas1
miR-329	PDGFAA	Notch2	IL-10	miR-26b-3p		Gas1
miR-140		Notch2	IL-10, decorin	miR-429		Gas1, Tim1
miR-204	TNF-α	Gas1	IL-10	miR-128-1-5p		Gas1
miR-98	IL-1α		IL-10	miR-144		Gas1
miR-665		IL-10, Notch 2 (3 sites), Tim1		miR-2985		Gas1
miR-335		IL-10, Notch2, Tim 1		miR-301a		Prolactin
miR-495		IL-10 (2 sites), Notch 2, Gas1 (2 sites)		miR-362		Tim1
miR-338		IL-10, Notch2		miR-451		Tim1
miR-200b, c			Decorin	miR-409-5p		Tim1
miR-223			Decorin	miR-218a		Tim1
miR-499		Decorin (2 sites), Gas1		miR-369-5p		Tim1
miR-542-3p		Decorin, Tim1		miR-434		IL-22
miR-138-1	B7–1/CD80	Notch2		miR-379	TREM1, FGF-BP
miR-196c	Decorin, TNF-α			miR-217	Notch 2, IL-1α

indicates a functional but nonpredominant miRNA as indicated by miRbase.