Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats

Figure 10

Testicular expression of Bax protein was detected using immunohistochemical staining in (a) control, (b) cisplatin (CDDP), (c) olive leaf extract (OLE), and (d) OLE + CDDP groups. In the control and OLE groups, Bax-positive brown-stained cells were sparse and weakly immunostained. However, many testicular cells exhibited apoptosis and were stained brown (Bax positive) due to CDDP. In the OLE + CDDP group, the number of Bax-positive cells was markedly increased. (400x).

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