Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats

Figure 11

Testicular expression of proliferating cell nuclear antigen (PCNA) protein was detected using immunohistochemical staining in (a) control, (b) cisplatin (CDDP), (c) olive leaf extract (OLE), and (d) OLE + CDDP groups. In the control and OLE groups, PCNA-positive brown-stained cells were moderately to strongly immunostained. However, many testicular cells were weakly stained with brown color due to CDDP. In the OLE + CDDP group, the number of PCNA-positive cells was markedly increased. (400x).

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