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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 8596903, 6 pages
Review Article

Role and Possible Mechanisms of Sirt1 in Depression

1National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Department of Neurobiology, Shanxi Medical University, No. 56 Xin Jian South Road, Taiyuan, Shanxi 030001, China
2Department of Environmental Health, Shanxi Medical University, No. 56 Xin Jian South Road, Taiyuan, Shanxi 030001, China
3Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

Correspondence should be addressed to Xiaorong Yang; moc.361@225225_gnor

Received 13 September 2017; Revised 18 November 2017; Accepted 4 December 2017; Published 31 January 2018

Academic Editor: Reiko Matsui

Copyright © 2018 Guofang Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD+ and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target. In this short review article, we attempt to present an up-to-date knowledge of depression and Sirt1 of the sirtuin family, describe the different effects of Sirt1 on depression, and further discuss possible mechanisms of Sirt1 including glial activation, neurogenesis, circadian control, and potential signaling molecules. Thus, it will open a new avenue for clinical treatment of depression.