Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

Figure 4

Salidroside (SAL) alleviates oxidative stress and suppresses NLRP3 inflammasome activation in db/db mice. After treatment with SAL (100 mg·kg⁻¹·d⁻¹) for 8 weeks, serum and liver tissues were obtained from wild-type (WT) and db/db mice. The SOD activity (a) and MDA content (b) in serum and liver tissues were measured. The expressions levels of TXNIP, NLRP3, caspase-1, and IL-1β in the liver tissues were detected by immunoblot (c). , versus WT treated with vehicle; , versus db/db mice treated with vehicle. Values are means ± s.e.m. ((a) and (b): ; (c): ).

(a)

(b)

(c)