Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme

Figure 1

Structural analysis of the studied longevity-related genes. (a) SOX2 gene (OMIM 184429) location in chromosome 3q26.33. The complete gene spans 2513 bases of genomic DNA (NC_000003.12; Chr 3: 181,711,924 to 181,714,436, plus strand; human genome assembly GRCh38). This intronless gene encodes a member of the SRY-related HMG-box family of transcription factors (translation length: 317 amino acids). SOX2 refers to the primary and predominant transcript of the SOX2 gene. The high-mobility group box domain amino acid sequence in the SOX2 transcription factor is highlighted by green color and the DNA-binding domain sequences are brown colored. (b) NANOG gene (OMIM: 607937) location in chromosome 12p13.31. The complete gene spans 11,348 bases of genomic DNA (NC_000012.12; Chr 12: 7,787,794 to 7,799,141, plus strand). The encoded protein (305 amino acids). (c) OCT3/4 gene (OMIM: 164177) location in chromosome 6p21.33. The gene spans 1420 bases of genomic DNA (NC_00006.12; genomic coordinates (GRCh38): 6: 31,164,337-31,170,693, minus strand). The gene encodes a transcription factor (360 amino acids) containing a POU-specific homeodomain (blue amino acid sequences) and DNA-binding domain (brown amino acid sequences). MW: molecular weight; Da: Dalton; aa: amino acids (data source: http://Genecards.org, http://Ensembl.org and UniProtKB).

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