Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice

Figure 1

Hemin ameliorated muscle mass loss and mitigated the protein breakdown rates. (a) Gross comparisons of muscle mass (8-week-old mice, 3 days after CLP surgery). (b) The weight of the solei from mice in the hemin group was improved, especially on days 3, 5, and 7 after surgery. (hemin vs. CLP), . (c) Protein breakdown rates as measured by the tyrosine concentration. (control vs. CLP), (hemin vs. CLP), (ZnPP vs. hemin), .

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