Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

Table 2

Effect of Cas on cardiac efficiency, contraction, and relaxation rates.

	Control; ()	Cas III-ia; ()	Cas II-gly; ()	Cas III-Ea; ()	Doxo; ()
Cardiac efficiency (RPP · MVO2^−1)	6.2 ± 0.25	3.2 ± 0.4	4.8 ± 0.81	3.3 ± 0.2	2.8 ± 0.1
+dP/dt × 1000 (mmHg·s^−1)	4.2 ± 0.41	2.4 ± 0.20	2.0 ± 0.13	2.4 ± 0.23	2.1 ± 0.23
−dP/dt × 1000 (mmHg·s^−1)	−3.3 ± 0.22	−1.0 ± 0.16	−0.7 ± 0.09	−0.8 ± 0.13	−0.8 ± 0.18

Rat hearts were treated with Cas or Doxo at the IC₅₀. CE: cardiac efficiency; RPP: rate-pressure product; MVO₂: myocardial oxygen consumption; +dP/dt: contraction rate; −dP/dt: relaxation rate. Values are mean ± SEM. versus control ( experiments at least for each treatment).