Research Article
Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats
Figure 5
Effect of Q7 and ascorbate on the vascular response in the intact rat aorta. The quinone increased the contractile response to PE and impaired ACh-induced vasodilation. The concentration-response curves to PE (10−9 to 10−5 M) (a) and ACh (10−9 to 10−5 M) in the intact aortic rings of rats (b) in the presence or absence (control) of 10−5 M Q7 or 2 mM ascorbate (Asc). Arteries were preincubated with Q7 or ascorbate for 30 min. Values are mean ± standard error of the mean of 5 experiments. Statistically significant differences: , , and versus control.
| (a) |
| (b) |