Research Article

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-κB-Mediated Inflammation

Figure 2

Andro treatment prevents diabetes-induced cardiac fibrosis in vivo. (a) Representative Sirius Red staining (upper panel) and Masson’s trichrome staining (lower panel). (b) Quantification of Sirius Red-stained collagen in the myocardium. (c–f) Real-time qPCR analysis was performed to detect the mRNA expression of the fibrosis-associated genes, including collagen I, collagen Ш, TGF-β1, and FN in the myocardial tissues. compared to control; compared to DM.