Partial Inhibition of HO-1 Attenuates HMP-Induced Hepatic Regeneration against Liver Injury in Rats

Figure 3

HO-1 haplodeficiency results in decreased proliferation and suppresses HMP-induced elevation of HO-1. (a) Representative sections from HO-1^+/− and WT (HO-1^+/+) rats at the indicated time points after HSLT (; scale bar: 200 μm). The liver sections were stained with anti-Ki67 (red) and were counterstained with DAPI (blue). (b) Quantification of the percentage of Ki67-labelled nuclei. (c) Protein expression and quantitative data () of HO-1 in liver tissues were analysed on day 7 in vivo and (d) at 6 h in vitro via western blotting. The data represent the mean ± SD. (b) , versus HO-1^+/+ group at 0 d; versus HO-1^+/+ rats of the same experimental group; (c, d) , versus HO-1^+/+ rats of the same experimental group; compared with OLT HO-1^+/+ group; , compared with SCS HO-1^+/+ group.

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