Partial Inhibition of HO-1 Attenuates HMP-Induced Hepatic Regeneration against Liver Injury in Rats

Figure 4

HO-1 haplodeficiency attenuates the liver recovery effects of HMP. (a) Histological analysis of livers from HO-1^+/− and WT (HO-1^+/+) rats on day 7 in vivo and (b) at 6 h in vitro by haematoxylin and eosin staining (; scale bar: 200 μm). (c) L-FABP was analysed by ELISA at the indicated times in vivo and (d) in vitro (). (e) Representative livers from rats before and 7 days after HSLT, indicating the differences in liver size and regeneration ratios (resected/regenerated weight), which were calculated to estimate the extent of liver regeneration between HO-1^+/− and WT (HO-1^+/+) rats (). The data represent the mean ± SD. (a, b, e) versus HO-1^+/+ rats of the same experimental group; compared with OLT HO-1^+/− group; , versus SCS HO-1^+/+ group; versus SCS HO-1^+/− group. (c) versus HO-1^+/+ rats of the same experimental group at 3 d; versus HO-1^+/− rats of the same experimental group at 7 d; versus SCS HO-1^+/− group at 7 d. (d) versus HO-1^+/+ rats of the same experimental group at 6 h; versus SCS HO-1^+/+ group at 6 h.

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