Research Article
Partial Inhibition of HO-1 Attenuates HMP-Induced Hepatic Regeneration against Liver Injury in Rats
Figure 6
HO-1 haplodeficiency partly prevents HMP-induced proliferation. (a) Representative sections and quantification of the percentage of Ki67-labelled nuclei from HO-1+/− and WT (HO-1+/+) rats on day 7 in vivo and (b) at 6 h in vitro (; scale bar: 200 μm). The liver sections were stained with anti-Ki67 (red) and were counterstained with DAPI (blue). (c) Transcriptomic (qRT-PCR) analysis of P27 in liver tissues from HO-1+/− and WT (HO-1+/+) rats on day 7 in vivo and (d) at 6 h in vitro (). The data represent the mean ± SD. , versus HO-1+/+ rats of the same experimental group; compared with OLT HO-1+/+ group; , compared with SCS HO-1+/+ group.
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