Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress
Table 7
The effects of SI on oxidative stress-related factors in serum, liver, and muscle of CFS mice.
CTRL
Model
SI (g/kg)
GS (g/kg)
0.25
0.5
1
0.05
Serum
MDA (nmol/mL)
22.4 ± 2.6
28.2 ± 1.5
21.8 ± 3.0
20.2 ± 1.4
22.1 ± 0.9
19.9 ± 1.2
ROS (U/mL)
203.3 ± 19.4
263.1 ± 9.0#
237.3 ± 15.1
232.5 ± 21.2
221.7 ± 16.8
224.4 ± 23.5
SOD (U/mL)
158.2 ± 11.2
129.7 ± 7.6#
137.6 ± 8.7
139.7 ± 11.9
154.8 ± 23.6
142.2 ± 21.1
GSH-Px (U/mL)
230.4 ± 29.8
192.0 ± 15.5#
209.2 ± 27.0
203.5 ± 19.8
218.7 ± 21.2
220.8 ± 10.6
Liver
MDA (nmol/mgprot)
4.5 ± 0.5
5.6 ± 0.7#
5.3 ± 1.3
5.5 ± 0.7
4.5 ± 0.9∗
4.5 ± 0.6∗
ROS (U/mgprot)
384.8 ± 41.6
449.2 ± 9.4#
420.3 ± 29.6
372.2 ± 39.8
379.1 ± 29.7
358.7 ± 20.2
SOD (U/mgprot)
136.1 ± 12.2
105.4 ± 8.2##
125.3 ± 25.1
128.5 ± 24.5
120.4 ± 30.2
136.9 ± 23.9
GSH-Px (U/mgprot)
172.7 ± 13.6
110.5 ± 13.2##
163.9 ± 23.5
169.5 ± 24.5∗
157.6 ± 16.8
168.2 ± 27.4
Muscle
MDA (nmol/mgprot)
6.1 ± 1.2
7.5 ± 1.1#
6.7 ± 1.2
6.3 ± 1.4
6.1 ± 0.7
6.0 ± 0.8
ROS (U/mgprot)
336.5 ± 39.8
402.2 ± 26.8##
423.2 ± 34.2
358.0 ± 37.9
369.7 ± 38.0
349.6 ± 36.2
SOD (U/mgprot)
289.6 ± 48.6
210.2 ± 19.8#
277.7 ± 35.4
297.2 ± 66.7
311.1 ± 29.7
287.9 ± 42.9
GSH-Px (U/mgprot)
167.7 ± 61.7
150.6 ± 30.7#
160.0 ± 47.1
170.5 ± 33.2
165.2 ± 48.1
174.0 ± 47.3
Treatment with SI (0.25 g/kg, 0.5 g/kg, and 1.0 g/kg) and GS (0.05 g/kg) for 32 days in CFS mice; the levels of MDA and ROS and the activities of SOD and GSH-Px in serum, liver, and muscle were detected. The data were analyzed using a one-way ANOVA followed by Dunn’s test and expressed as (). and versus the control group; and versus the model group. SI: S. imbricatus; GS Ginsenoside.
