Flavocoxid, a Natural Antioxidant, Protects Mouse Kidney from Cadmium-Induced Toxicity

Figure 5

Ultrastructural organization of the glomeruli of kidneys from mice of control plus vehicle (0.9% NaCl, 1 ml/kg/day i.p.), control plus flavocoxid (20 mg/kg/day i.p.), CdCl₂ (2 mg/kg/day i.p.) plus vehicle, and CdCl₂ plus flavocoxid groups. (a, b) In both control plus vehicle and control plus flavocoxid-treated mice, glomeruli show normal morphology of either the podocytes or the endothelial cells. (c) In CdCl₂-challenged mice, podocytes are elongated and fewer, and their contacts with the capillaries are lacking (arrow). (d) In CdCl₂ plus flavocoxid-treated mice, glomerular morphology was superimposable to controls (scale bar: 4 μm).

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