Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity

Figure 6

Effect of fisetin on myocardial tissue ultrastructure examined by electron microscope (EM) and mitochondrial biogenesis makers determined by qRT-PCR technique. (a) Representative EM picture of myocardial tissue processed from sham or sham ± fisetin-treated animals. (b) Shown is the EM image of myocardial tissue from animals subjected to IRI; yellow arrowheads indicate that mitochondria are markedly abnormal, with varying size and densities and characterized by the loss of matrix and cristae. (c) EM picture reveals that fisetin attenuates mitochondrial damage induced by IRI. (d) The mRNA expression of mitochondria biogenesis markers; /group; versus sham/sham ± fisetin; versus I/R.

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