Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways

Figure 1

Effect of guarana hydroalcoholic extract (GHE) treatment on polyQ aggregation in C. elegans transgenic models of Huntington disease. (a) The C. elegans strain HA759 expressing Htn-Q150 in ASH neurons were treated with 10 or 50 mg/mL GHE from L1 until 4-day-old adulthood. Using a fluorescent microscope, ASH neuron death was assessed by loss of bilateral GFP fluorescence. Treatment with 10 mg/mL GHE prevented ASH neuronal death. , two-tailed Student -test. (b) The C. elegans strain AM141 expressing polyQ₄₀ in muscle cells were treated with either 10 or 50 mg/mL GHE from L1 until 1-day-old adulthood. Images were acquired with a fluorescence microscope, and aggregates were counted. Treatment with either 10 or 50 mg/mL GHE reduced the number of aggregates. and , two-tailed Student -test.

(a)

(b)