Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways

Figure 8

Effect of guarana hydroalcoholic extract (GHE) treatment on protein degradation activity and lysosome-related organelle levels (or protein homeostasis). (a) Animals were treated with either 10 or 50 mg/mL GHE from L1 until L4. Proteasome chymotrypsin-like activity was monitored by SLLVY-MCA digestion in worm extracts containing equal amounts of total protein. , two-tailed Student -test. (b) GFP::LGG-1 animals were treated with either 10 or 50 mg/mL GHE from L1 until L4. GFP::LGG-1 puncta were counted in seam cells to quantify the mean number of puncta per seam cell. , two-tailed Student -test.

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