The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Table 1

Effect of estradiol and sinapic acid on the body mass gain and mass of selected organs in ovariectomized rats.

Parameter/group	SHAM	OVX	ESTR	SA5	SA25
Body mass at the start of drug administration (g)	212.2 ± 3.0	222.0 ± 4.3	222.5 ± 3.0	225.0 ± 4.8	224.4 ± 4.9
Body mass after 4 weeks of drug administration (g)	235.3 ± 3.5	271.8 ± 5.0	257.7 ± 4.3	272.1 ± 6.5	271.0 ± 6.4
Body mass gain after 4 weeks (g)	23.1 ± 1.9	49.8 ± 1.8	35.2 ± 3.2^###	47.1 ± 2.4	46.6 ± 2.7
Uterus mass (g)	0.434 ± 0.036	0.082 ± 0.005	0.181 ± 0.010^###	0.068 ± 0.005	0.071 ± 0.002
Thymus mass (g)	0.377 ± 0.022	0.596 ± 0.044	0.500 ± 0.023^#	0.625 ± 0.037	0.613 ± 0.038
Kidney mass (g)	0.758 ± 0.020	0.789 ± 0.016	0.785 ± 0.029	0.760 ± 0.014	0.768 ± 0.013
Liver mass (g)	5.906 ± 0.149	6.382 ± 0.156	6.518 ± 0.132	6.365 ± 0.315	6.330 ± 0.175

Sinapic acid at doses of 5 mg/kg (SA5) and 25 mg/kg (SA25) or estradiol ((ESTR) 0.2 mg/kg) was administered orally to rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats. Results are presented as the mean ± SEM. One-way ANOVA followed by Fisher’s LSD test was used for evaluation of statistical significance of the results., , and : significantly different from the SHAM control rats. , : significantly different from the OVX control rats. No statistically significant differences in results for the body mass at the start of drug administration, as well as kidney and liver mass, were demonstrated in ANOVA.