Research Article
The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats
Table 2
Effect of estradiol and sinapic acid on the serum concentrations of nonenzymatic antioxidants and the serum activity of antioxidative enzymes.
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Sinapic acid at doses of 5 mg/kg (SA5) and 25 mg/kg (SA25) or estradiol ((ESTR) 0.2 mg/kg) was administered orally to rats once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats; GSH: reduced glutathione; GSSG: oxidized glutathione; TAC: total antioxidant capacity; SOD: superoxide dismutase; CAT: catalase. Results are presented as the mean ± SEM. The level of TAC is presented in Trolox equivalents. One unit of SOD was the amount of enzyme needed to exhibit 50% dismutation of the superoxide radical. One-way ANOVA followed by Fisher’s LSD test was used for evaluation of statistical significance of the results. , : significantly different from the SHAM control rats. , : significantly different from the OVX control rats. No statistically significant differences in results for GSSG, GSH/GSSG ratio, TAC, and CAT were demonstrated in ANOVA. |