The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Table 3

Effect of estradiol and sinapic acid on the serum biochemical markers of liver and kidney function in ovariectomized rats.

Parameter/group	SHAM	OVX	ESTR	SA5	SA25
AST (U/l)	39.22 ± 3.38	34.72 ± 2.78	35.83 ± 3.62	38.14 ± 4.08	40.35 ± 3.73
ALT (U/l)	23.68 ± 2.19	23.52 ± 1.38	22.78 ± 1.83	23.69 ± 2.08	28.38 ± 3.61
Uric acid (mg/dl)	1.13 ± 0.07	1.18 ± 0.17	1.10 ± 0.10	0.86 ± 0.06	1.00 ± 0.06
Urea (mg/dl)	25.72 ± 4.74	35.36 ± 4.19	38.45 ± 5.61	32.46 ± 3.63	37.49 ± 2.46
Creatinine (mg/dl)	0.449 ± 0.022	0.476 ± 0.019	0.431 ± 0.035	0.472 ± 0.031	0.415 ± 0.053

Sinapic acid at doses of 5 mg/kg (SA5) and 25 mg/kg (SA25) or estradiol ((ESTR) 0.2 mg/kg) was administered orally to rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats. Results are presented as the mean ± SEM. One-way ANOVA was used for evaluation of statistical significance of the results. No statistically significant differences in results for AST, ALT, uric acid, urea, and creatinine were demonstrated in ANOVA.