Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

Figure 4

Melatonin suppressed ox-LDL-induced NLRP3 inflammasome activation in macrophages. (a) The Sirt3 activity examined by the ELISA assay. versus the Con group; versus the ox-LDL group; and versus the ox-LDL + MEL group. (b) The IL-1β secretion level in macrophages examined by the ELISA assay. versus the Con group; versus the ox-LDL group; and versus the ox-LDL + MEL group. (c–g) The Sirt3, NLRP3, ASC, caspase-1, and caspase-1-pro expressions were examined by the Western blot assay. versus the Con group; versus the ox-LDL group; and versus the ox-LDL + MEL group.

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