Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs

Figure 5

The effect of HC feeding and treatment with metformin or pioglitazone on BRS. (a) The pressor effect of different doses of PE in different treatment groups. and # denote versus response at corresponding PE doses in control or HC-fed rats, respectively. Statistical significance was determined by two-way ANOVA followed by Sidak’s post hoc test. (b) The reflex bradycardic response to different doses of PE in different treatment groups. (c) Best fit regression lines for the correlation between changes in MAP in response to increasing PE doses and reflex change in HR in different treatment groups. (d) Slope of the best fit regression line of the ΔMAP versus ΔHR relationship representing BRS in response to PE treatment. and # denote versus slope in control or HC-fed rats, respectively. Statistical significance was determined by ANOVA followed by Dunnett post hoc test. (e) Best fit regression lines for the correlation between changes in MAP in response to increasing SNP doses and reflex change in HR in different treatment groups. (f) Slope of the best fit regression line of the ΔMAP versus ΔHR relationship representing BRS in response to SNP treatment. Depicted data represent mean ± SEM of values obtained from eight rats in each treatment groups.

(a)

(b)

(c)

(d)

(e)

(f)