Sepsis and Oxidative Stress in the Newborn: From Pathogenesis to Novel Therapeutic Targets

Table 3

Animal studies of novel antioxidant treatments in neonatal sepsis.

Model	Interventional procedures	Outcomes	Ref.
Edaravone
Piglets	CLP alone or CLP and IV continuous edaravone infusion	Reduced TH at 1 hour after CLP, reduced nitrite-nitrate at 3 and 6 hours, reduced HMGB-1, delayed TNF-alpha surge, increased mean arterial pressure, reduced heart rate, longer survival time in treated versus untreated animals	[117]
Piglets	CLP alone or CLP and IV continuous edaravone infusion	Reduced pulmonary hypertension in treated versus untreated animals; Mean pulmonary artery pressure/mean systemic arterial pressure ratio positively related to TNF-alpha levels	[118]
Endothelin-1 receptor antagonist
Piglets	CLP alone or CLP and IV continuous ETR-P1/fl infusion or controls	Reduced nitrite-nitrate, TNF-alpha, HMBG-1, reduced pulmonary hypertension in CLP-treated animals versus CLP alone	[123]
Piglets	CLP alone or CLP and IV continuous ETR-P1/fl infusion or controls	Reduced TH, OSI, IL-6 at 3 and 6 hours post-LP	[124]

CLP: cecal ligation perforation; TH: total hydroperoxide; OSI: oxidative stress index; HMGB-1: high mobility group box 1.