SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease

Figure 3

Linear regression analysis between Sirtuin 1 (SIRT1) activity in peripheral blood mononuclear cells (PBMCs) and forced expiratory volume in 1 second (FEV1) values (a); between SIRT1 activity in peripheral blood mononuclear cells (PBMCs) and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio values (b); and between SIRT1 activity in peripheral blood mononuclear cells (PBMCs) and serum TEAC (c). SIRT1 activity was determined in the nuclei extracted from PBMCs of healthy nonsmokers (HnS), healthy smokers (HS), and COPD patients (COPD). The multivariate analysis was also adjusted for age, gender, BMI, smoking pack/years, comorbidity, and drugs.

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