Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner

Figure 4

Effect of NaHS on cardiac configuration and function in WT mice and SIRT3 KO mice after ISO administration. Male 129S1/SvImJ (WT) and SIRT3 knockout (KO) mice at 10 weeks of age were administrated with NaHS (50 μmol/kg/d) or normal saline (NS) once daily. After 2 weeks, the mice were given isoproterenol (ISO, 60 mg/kg) by intraperitoneal injection followed by NaHS or NS administration once daily for another 2 weeks. (a) Representative 2-D M-mode echocardiograms of the heart by echocardiography. (b–c) IVS and LVPW thickness were quantified by echocardiography. (d–e) EF and FS were quantified by echocardiography. Plots represent the mean ± SEM; . Statistical significance: compared with WT + NS; , compared with WT + ISO; compared with SIRT3 KO + NS.

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