Prophylactic Zinc and Therapeutic Selenium Administration Increases the Antioxidant Enzyme Activity in the Rat Temporoparietal Cortex and Improves Memory after a Transient Hypoxia-Ischemia

Figure 4

Differential effect of the combined treatment with zinc and selenium on the enzymatic activity and transcription of superoxide dismutase in the rat hypoxia-ischemia model. (a) Enzymatic activity of SOD, (b) mRNA levels of Sod1, (c) mRNA levels of Sod2, and (d) mRNA levels of Sod3. CCAO: common carotid artery occlusion for 10 min; Zn + CCAO: chronic zinc administration before CCAO; Zn + CCAO + Se: chronic zinc administration before CCAO followed by selenium administration. The values were normalized against the control group. Each value represents of 5 independent experiments made in triplicate. , one-way ANOVA with post hoc Dunnett’s test when compared to the control untreated group; , Student’s -test when compared with the CCAO group.

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