Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 4

Research Article

Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4

Figure 4

Photomicrographs of rat heart sections stained by HE. (a, b) Heart sections in control (G1) and GSPE (G2) groups revealed normal myofibrillar structure with striations. (c) Heart sections in rats treated with Boldenone (G3) showed severe myocardial lesions due to marked myocardial hypertrophy (white arrows), necrosis, marked interstitial fibrosis (black arrows), misshapen nuclei, moderate focal hemorrhage, and moderate infiltration of leukocytes. (d) Heart sections in posttreated rats with Boldenone and GSPE (G4) exhibited moderate myocardial hypertrophy (white arrows) and interstitial fibrosis (black arrows).