Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation

Figure 3

Gankyrin potentiates mTORC1 signaling via PGK1/AKT. (a) Overexpressed gankyrin activates AKT/mTORC1 signaling in gastric cancer cell lines, MKN45, MKN74, and AGS. The protein levels of PGK1, pAKT, AKT, pS6 K1, S6 K1, p4E-BP1, and 4E-BP1 were analyzed by immunoblotting. (b) The correlation plot of gankyrin and PGK1 mRNA level in 414 gastric cancer samples was presented by analyzing the TCGA cancer genome database.

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