Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways

Figure 3

Resveratrol inhibits proliferation and promotes apoptosis in pancreatic cancer cells. (a, b) Two PCa cells, that is, Panc-1 and Mia paca-2, were treated with increasing doses of RSV (0, 25, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h and subjected to an MTT assay for the assessment of the cell viability. (c, e) Flow cytometry was performed to detect the effects of resveratrol on apoptosis in the Panc-1 and Mia paca-2 cells. (d, f) The effects of resveratrol on the colony-forming ability of Panc-1 and Mia paca-2 cells. Images are representative of three independent experiments (scale bar: 1 cm). Column: mean; bar: SD. and .

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