Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
Effects of MI/R injury on nondiabetes and diabetic rats. Nondiabetes and diabetic rats were subjected to 45 min of ischemia followed by 3 h of reperfusion. N: nondiabetic rats; D: STZ-induced diabetic rats; S: sham operation; IR: ischemia/reperfusion; TubA: tubastatin A. (a) Infarct area versus area at risk (IA/AAR × 100%). (b) Serum levels of LDH. (c) Serum levels of CK-MB. (d) Cardiac tissue H2O2 concentration. (e) Cardiac tissue O2− production. All the results are presented as mean ± SEM, /group. versus NIR group, versus NS group, and versus DS group.
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